The Canadian singer, who is working on a new album, was out of the recording studio for six years until her return in 2011.
Tom had recently cancelled a string of performances due to an illness in his family.
Tom Jones' wife Linda has passed away after a "short but fierce battle with cancer".
Lady Melinda Rose Woodward, known as Linda, died on Sunday morning at Cedars Sinai Hospital in L.A.
In a statement released by Sir Tom's agent, he said Linda was "surrounded by her husband and loved ones and passed away peacefully".
The pair were childhood sweethearts, growing up together in Treforest, Pontypridd and had been married for 59 years.
They had one son together, Mark, who is also Tom's manager.
Tom had recently cancelled performances due to a "serious illness" in his family.